Afoxolaner for dogs is used to treat and control flea and tick infestations in dogs. After being ingested by a dog, afoxolaner is distributed throughout the dog’s body. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. Gihi Chemicals also has afoxolaner for cats. Sometimes afoxolaner is used for the treatment of sarcoptic mange or demodectic mange. When afoxolaner is prescribed for the treatment of mange, it is referred to as "extra label" or "off label" use.
Afoxolaner Synonym
4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2, 2, 2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide; Afoxolaner; 1-NaChemicalbookphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2, 2, 2-trifluoroethyl)amino]ethyl]-; Afoxolanerfandachem
Afoxolaner Safety
CAS No.: 1093861-60-9
EC No.: 832-051-7
MF: C26H17ClF9N3O3
MW: 62.587
Parameters of Afoxolaner
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Item
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Specification
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Results
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Appearance
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White To Off-white Crystalline Powder
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Complies
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Identification
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HPLC: HPLC Retention Time Confirms To Standard
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Complies
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Melting Point
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148-155℃
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148-150℃
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Water
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≤0.1%
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0.07%
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Residue Solvents
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Dichloromethane≤600ppm
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N.D.
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Isopropyl Acetate≤5000ppm
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N.D.
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Isopropanol≤890ppm
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2ppm
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N, N-Dimethylformamide≤880ppm
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N.D.
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Methanol≤3000ppm
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N.D.
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Tetrahydrofuran≤720ppm
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N.D.
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Triethylamine≤5000ppm
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N.D.
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Residue On Ignition
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≤0.1%
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0.02%
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Related Substances
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Impurity D≤0.15%
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N.D.
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Impurity F≤0.15%
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0.08%
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Individual Unknown Impurity≤0.10%
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0.06%
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Total Impurities≤1.00%
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0.38%
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Assay(Anhydrous Substance)
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98.0%~102.0%
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99.10%
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Packing:
100g/bag; 500g/bag; 1kg/bag
Recommended storage method:
Store in a cool, dry and ventilated place.
Recommended storage temperature:
2 - 8 °C
Product usage:
Pharmaceutical intermediates
Benefits of Afoxolaner
Treat and control flea and tick infestations in dogs.
When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal.
The treatment of sarcoptic mange or demodectic mange.
When afoxolaner is prescribed for the treatment of mange, it is referred to as 'extra label' or 'off label' use.
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